Micro-bioreactor array for controlling cellular microenvironments
نویسندگان
چکیده
منابع مشابه
Micro-bioreactor array for controlling cellular microenvironments.
High throughput experiments can be used to spatially and temporally investigate the many factors that regulate cell differentiation. We have developed a micro-bioreactor array (MBA) that is fabricated using soft lithography and contains twelve independent micro-bioreactors perfused with culture medium. The MBA enables cultivation of cells that are either attached to substrates or encapsulated i...
متن کاملLiquid Marble as Micro - Bioreactor
Liquid marbles can be used as micro-bioreactors, thanks to their unique properties. On the one hand, the highly porous, non-adhesive, and hydrophobic shell of liquid marbles efficiently inhibits any direct contact between the liquid core of the marble and the surface that supports it, while allowing oxygen and carbon dioxide to pass through. On the other hand, the finite volume of liquid in liq...
متن کاملOptimization of Bioreactor Cultivation Parameters by Taguchi Orthogonal Array Design for Enhanced Prodigiosin Production
One of the major steps toward the industrialization of the microbial product(s) is to optimize the cultivation conditions at the large-scale bioreactor and successfully control the microbial behavior within a large scale production environment. Statistical Design of Experiment was proven to optimize a vast number of microbial processes to achieve robustness and explore possible interactions...
متن کاملMicroenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors
Because of the accelerated proliferation of cancer cells and the limited distance that molecular oxygen can diffuse from functional tumor blood vessels, there appears to be a unique histology in malignant solid tumors, conglomerates of micro tumor cords. A functional blood vessel exists at the center of each tumor cord and is sequentially surrounded by well-oxygenated, oxygen-insufficient, and ...
متن کاملEngineering of synthetic cellular microenvironments: implications for immunity.
In this article, we discuss novel synthetic approaches for studying the interactions of cells with their microenvironment. Notably, critical cellular processes such as growth, differentiation, migration, and fate determination, are tightly regulated by interactions with neighboring cells, and the surrounding extracellular matrix. Given the huge complexity of natural cellular environments, and t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lab on a Chip
سال: 2007
ISSN: 1473-0197,1473-0189
DOI: 10.1039/b700063d